How Do You Reduce Nephrotoxicity?

Is acyclovir bad for your kidneys?

Although the drug is well tolerated, severe nephrotoxicity, which often leads to acute renal failure, has been observed in patients [4, 7].

Acyclovir-induced renal failure occurs in approximately 12–48 % of cases [4]..

What are the long term side effects of acyclovir?

Serious side effectsUnusual changes in your mood or behavior. Symptoms can include: … Decrease in your red blood cells and platelets. Symptoms can include: … Liver problems.Muscle pain.Skin reactions. Symptoms can include: … Changes in your vision.Kidney failure. Symptoms can include: … Allergic reaction. Symptoms can include:

Can kidneys repair themselves?

It was thought that kidney cells didn’t reproduce much once the organ was fully formed, but new research shows that the kidneys are regenerating and repairing themselves throughout life. Contrary to long-held beliefs, a new study shows that kidneys have the capacity to regenerate themselves.

What are signs of nephrotoxicity?

SymptomsDecreased urine output, although occasionally urine output remains normal.Fluid retention, causing swelling in your legs, ankles or feet.Shortness of breath.Fatigue.Confusion.Nausea.Weakness.Irregular heartbeat.More items…•

What foods help repair kidneys?

A DaVita Dietitian’s Top 15 Healthy Foods for People with Kidney DiseaseRed bell peppers. 1/2 cup serving red bell pepper = 1 mg sodium, 88 mg potassium, 10 mg phosphorus. … Cabbage. 1/2 cup serving green cabbage = 6 mg sodium, 60 mg potassium, 9 mg phosphorus. … Cauliflower. … Garlic. … Onions. … Apples. … Cranberries. … Blueberries.More items…

Is drinking a lot of water good for your kidneys?

When you drink too much water, your kidneys can’t get rid of the excess water. The sodium content of your blood becomes diluted. This is called hyponatremia and it can be life-threatening.

Why does cisplatin need hydration?

Hydration is recommended to induce diuresis and reduce the concentration of cisplatin in the kidneys. Isotonic saline (0.9% sodium chloride) is recommended for hydration fluids, and many centers also include potassium and magnesium in these hydration fluids due to the risk of electrolyte wasting.

Can cisplatin cause kidney damage?

A known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI may result in chronic kidney disease.

What causes nephrotoxicity?

Nephrotoxicity can be defined as the adverse effect of substances on renal function (Perazella, 2009). These substances can include molds and fungi, cancer therapeutics such as cisplatin, antibiotics such as aminoglycosides, metals such as mercury, arsenic and lead, and drugs of abuse such as cocaine.

Can baking soda reverse kidney failure?

July 18 — FRIDAY, July 17 (HealthDay News) — A dose of baking soda a day may slow the progression of chronic kidney disease, a new study has found. The study included 134 advanced chronic kidney disease patients with metabolic acidosis, a condition caused by low bicarbonate levels.

How can I repair my kidneys naturally?

Keeping your kidneys healthy Healthy bodyStay hydrated. Drinking plenty of fluid will help your kidneys function properly. … Eat healthily. A balanced diet ensures you get all the vitamins and minerals your body needs. … Watch your blood pressure. … Don’t smoke or drink too much alcohol. … Keep slim to help your kidneys.

How is nephrotoxicity measured?

Nephrotoxicity can be diagnosed through a simple blood test. Evaluation of nephrotoxicity through blood tests includes the measurements of blood urea nitrogen (BUN), concentration of serum creatinine, glomerular filtration rate and creatinine clearance.

What happens if I stop taking acyclovir?

If you stop taking acyclovir too soon or skip doses, your infection may not be completely treated or may become more difficult to treat.

What drugs are toxic to kidneys?

Which Drugs are Harmful to Your Kidneys?Pain Medications. Your kidneys could be damaged if you take large amounts of over-the-counter medications, such as aspirin, naproxen and ibuprofen. … Alcohol. … Antibiotics. … Prescription Laxatives. … Contrast Dye (used in some diagnostic tests such as MRIs) … Illegal Drugs. … What should you do?

How bad is cisplatin?

Cisplatin may cause serious kidney problems. Tell you doctor right away if you have blood in urine, change in frequency of urination or amount of urine, difficulty in breathing, drowsiness, increased thirst, loss of appetite, nausea or vomiting, swelling of the feet or lower legs, or weakness.

How is nephrotoxicity treated?

The acute nephrotoxicity is reversible with dose modification. In contrast, chronic administration may cause a slowly irreversible renal failure secondary to renal tubular fibrosis and afferent arteriopathy with proteinaceous material. Tacrolimus causes renal injury in a fashion similar to cyclosporine.

How do you prevent acyclovir nephrotoxicity?

The risk of acyclovir induced nephropathy can be minimized with empiric IV fluids to establish euvolemia before drug administration, avoiding rapid infusion of the drug (infuse slowly over 1-2 hours), and adjusting the dose for renal function if necessary [1].

How do you prevent cisplatin nephrotoxicity?

The standard approach for prevention of CIN is the administration of lower doses of cisplatin in combination with full intravenous hydration prior and after cisplatin administration. Cisplatin-induced oxidative stress in the kidney may be prevented by natural antioxidant compounds.